Major changes in immune cell metabolism occur after activation and/or infection. These changes have a significant impact on the functions of cells and may be used to identify cell populations at distinct stages of development and/or differentiation, as well as reveal a recent history of antigen exposure. Importantly, there is an increasing number of ways to target T cell metabolism for therapy. Our preliminary results identified metabolic changes in CD4+ T cells from malaria and leishmaniasis patients. In this project, we will identify metabolic pathways employed by various CD4+ T cell subsets during disease. In addition, we will investigate how cell metabolism influences the function of these immune cells.
Professor Christian Engwerda | email@example.com