Recently, we delineated the mechanism in which graft-versus-host disease (GVHD), the major detrimental effect of allogeneic bone marrow transplantation, is enhanced by pathogenic colon-derived donor dendritic cells (DC) in a murine model. First, we will find the genetic signature of these DC using RNA sequence assay. Secondly, we will identify the equivalent human DC from post-transplant patient’s blood sample. The genetic profile of pathogenic colon-derived DC will provide us with a powerful biomarker to predict and treat severe GVHD.
Dr Motoko Koyama | Motoko.Koyama@qimrberghofer.edu.au