PhD project but may also be considered for a Honours project Dry lab/biostatistics project (not suitable for clinical students) The Translational Neurogenomics laboratory investigates the role of genetic factors in a range of psychiatric conditions, including schizophrenia, addiction, anxiety disorders and compulsive disorders. By researching a wide variety of symptoms that are typical of patients with a… READ MORE
What makes one at risk for having a mental health disorder? Investigating the regulatory role of genetic variants
PhD project but may also be considered for a Honours project Dry lab/bioinformatics project (not suitable for clinical students) The Translational Neurogenomics laboratory investigates the role of genetic factors in a range of psychiatric conditions, including schizophrenia, addiction, anxiety disorders and compulsive disorders. By researching a wide variety of symptoms that are typical of patients with… READ MORE
Using Parasite mRNA-sequencing and mathematical modelling to study how Plasmodium responds to the host in vivo
In collaboration with mathematical modeller, Professor Miles P. Davenport (UNSW, Sydney), we will use experimental models of malaria to examine an exciting new mechanism by which the host appears to control Plasmodium parasite numbers in vivo. We will use parasite RNA-seq and mathematical models developed by Prof Davenport to determine the molecular basis of this new phenomenon.
Using single-cell transcriptomics to study T cell responses in the gut during Graft-versus Host Disease
In collaboration with Dr. Motoko Koyama, we are interested in how CD4+ T-cells in the gut differentiate into an array of different effector states (Th1/Th17/iTreg) during Graft-versus-host-Disease, a common and severe complication following allogeneic stem cell transplantation. Using scRNA-seq and TCR transgenic CD4+ T cells we will explore how this process occurs in vivo.
Using single-cell transcriptomics and epigenomics to study CD4+ T cell memory in experimental malaria
Using recently developed Plasmodium-specific TCR transgenic CD4+ T cells, we will employ state-of-the-art single-cell techniques such as scRNA-seq and scATAC-seq to explore how T cells develop immunological memory during experimental malaria.
Using existing high-resolution single-cell transcriptomic data in a range of immune cells, we will determine to what extent individual genes are differentially spliced in individual cells during experimental malaria. We will use a range of existing bioinformatics packages, which will require Programming skills in R and/or Python.
Using high-throughput gene editing techniques to examine CD4+ T cell responses in vivo during experimental malaria
We will employ CRISPR/cas9 genome editing techniques with molecular barcoding in Plasmodium-specific CD4+ T cells. In combination with single-cell transcriptomics we aim to discover novel genes that control differentiation into distinct effector states.
This project will provide an exciting opportunity for an enthusiastic honours student to join the Lung Bacteria group at QIMR Berghofer Medical Research Institute. The student will work in the research area of Pseudomonas aeruginosa lung infection in cystic fibrosis (CF). In particular, the student will investigate antibiotic resistance mechanisms in P. aeruginosa, which causes… READ MORE
Avoiding destruction by immune cells is a hallmark of cancer, yet how tumors ultimately evade NK cell control remains incompletely defined. We have a project based upon the previously unrecognized TGF-b-dependent differentiation of conventional NK (cNK) cells in settings of lymphopenia and tumors. Strikingly, a higher proportion of cNK cells and their capacity for relatively… READ MORE
PhD project but may also be considered for an Honours project Motor neuron disease (also known as amyotrophic lateral sclerosis, ALS) is a devastating illness involving loss of motor neurons in the spinal cord. The disease normally leads to paralysis and death after 2-5 years, and there is no effective long-term treatment or cure. The… READ MORE
Investigating the role of Zinc transporters in autophagy and its role in the childhood neurodegenerative disorder, Batten Disease
PhD project but may also be considered for an Honours project Neuronal Ceroid Lipofuscinosis (also known as Batten disease) is a group of inherited lysosomal storage disorders that affect infants and children. The disease leads to rapid neurodegeneration and death and there are no treatments or cures. Little is known about Batten disease but each… READ MORE