The use of genomics in clinical practice has the potential to revolutionise healthcare delivery. Australian Genomics is a national network of more than 70 organisations aimed to integrate genomics into Australian healthcare, improving patient outcomes and facilitating faster diagnosis, early intervention, prevention and targeted therapy. Currently, genetic testing laboratories operate separately to classify and report (potential) disease-causing variants. Through our work in Australian Genomics, we aim to assess needs, barriers and solutions to a national effort to standardise disease gene variant classifications and facilitate sharing of genomic information (and information supporting variant classifications) across genetic testing laboratories. Our work also extends to the standardisation and sharing of variant information in a state-wide, Queensland setting through participation in the Queensland Genomics Health Alliance, a patient-centred, clinically led entity involved in the translation of genomics into Queensland healthcare. By working with organisations at a national and state level, and specialists in bioinformatics, genomics and economics – including researchers at QIMRB integrally involved in AGHA and QGHA activities (John Pearson, Nicola Waddell, Louisa Gordon) – we anticipate that sharing of variant will be implemented as routine practice, and translate to better quicker variant classification and thus better patient care in the clinical setting.