Currently, there is no established mechanism to collect Australian clinical data on the different liver diseases, nor monitor for long-term disease sequelae such as death and cancer. The development of a National database of chronic hepatitis C related liver disease with linkage to population-based Medicare, cancer and death registries would enable such data to be collected, including detailed information on the clinical characteristics, disease severity, natural history, treatment uptake and impact of treatment on disease progression for each of the major liver diseases. In order to assess the uptake and impacts of DAAs, a national registry was established (OPERA-C).
OPERA-C is an investigator initiated prospective study recruiting across 29 tertiary hospitals in Australia. The information gathered through this study will enable a better understanding of the current disease burden but also importantly, potentially identify barriers to appropriate patient care, better understand health resource utilization, and identify directions for further research. It will also be of major assistance in the planning and delivery of additional health and welfare services and revised models of care necessary to manage both the current and expected demand for treatment.