(Grant Montgomery, Zhen Zhen Zhao, Lisa Bowdler,)
We collaborate with Prof. Nick Hayward and the International Melanoma Genetics Consortium (GenoMEL) which has the primary objective of carrying out genome-wide linkage and association scans to map novel melanoma susceptibility genes and to clone and characterise genes contributing to melanoma risk. We have identified novel melanoma risk variants near MTAP and close to the cell cycle gene CDKN2A on chromosome 9. We are conducting genomic and functional studies to further characterize the casual variant(s) and gene/pathway responsible for increased melanoma risk. We are conducting gene expression analyses in melanoma cell lines and using next generation sequencing to identify all known variants across the target region.