We will delve further into the mechanism of action of EBC-46 in the treatment of cancer. This will include the use of analogues, both natural and synthetic, the latter coming from collaborations with Dr Craig Williams (University of Queensland) and Professor Giovanni Appendino (Piedmont, Italy). Availability of a fluorescent derivative will allow the distribution of EBC-46 to be mapped in vivo. Studies of the mechanism of action will focus on tumor-drug-host interactions.
Identifying plant compounds with potential for addressing health problems other than cancer.
We will continue to expand our screening of the rain forest library using a range of bioassays. This includes collaborations with Professor Denis Moss and Professor Denise Doolan.