PISA is the Prospective Imaging Study of Ageing: Genes, Brain and Behaviour.
QIMR Berghofer is leading an internationally collaborative, long-term study to identify healthy middle-aged Australians at high genetic risk of dementia.
PISA studies the interplay between genetic, epigenetic and environmental factors for dementia, and also aims to identify risk factors that could be modified through intervention – such as lifestyle choices.
The study is a unique international research resource, providing new links to studies into the causes of dementia, assisting clinical trials in dementia prevention, and bringing about new possibilities for translational research into this important public health issue.
PISA uses cutting edge imaging technologies to examine the neurobiological features associated with high risk for dementia, and identify the changes that lead to a patient’s transition from high risk to cognitive impairment.
The combined use of genetic risk scores and neurobiological markers creates a potential prognostic marker for dementia development.
Outcomes of the study will inform and establish a platform for future intervention programs that target preventing and treating dementia.