Prof Geoff Hill is a medical graduate of the University of Auckland and Haematologist, training in New Zealand and The Dana Farber Cancer Institute in Boston. He is a NHMRC Senior Principal Research Fellow and his immunology laboratory focuses on the interactions between cytokines, antigen presenting cells and regulatory T cells during transplantation.
Prof Hill was the 2005 Queenslander of the Year and recipient of the Transplantation Society of Australia and New Zealand 2009 Ian McKenzie Award and the 2015 Translational Research Institute National Prize for excellence within basic and clinical research in the transplant field. He is a Fellow of the Australian Academy of Health and Medical Science and received an NHMRC Australia Fellowship to translate new cytokine and cell based therapies into clinic practice.
Current QIMR Berghofer appointments
- 2015 – present: Senior Scientist, NHMRC Senior Principal Research Fellow
- 2015 – present: Coordinator Cancer Program
- 2015 – present: Clinical Director, Q-Gen Cellular Therapeutics
- 2011 – present: Qld Health Senior Clinical Research Fellow
- 2001 – present: Team Head, Bone Marrow Transplantation Laboratory
Other current appointments
- 2016 – present: Honorary Professor, University of Western Australia
- 2016 – present: Cancer Theme Leader, Brisbane Diamantina Health Partners NHMRC AHRTC
- 2013 – present: Director of Research, Cancer Care Services, The Royal Brisbane and Women’s Hospital
- 2005 – present: Honorary Professor, University of Queensland and Griffith University
- 2001 – present: Bone Marrow Transplant Physician and Haematologist, The Royal Brisbane and Women’s Hospital
- 2011 – 2015: NHMRC Australia Fellow, QIMR
- 2006 – 2010: NHMRC Practitioner Research Fellow, QIMR
- 2001 – 2006: Wellcome Trust Senior Overseas Research Fellow, QIMR
- 2001 – 2006: NHMRC Honorary Practitioner Research Fellow, QIMR
- 1999 – 2001: NHMRC Practitioner Research Fellow, Mater MRI
- 1996 – 1999: Research Associate, Harvard University, Dana-Farber Cancer Institute Boston USA
- 1993 – 1996: Senior Registrar, Clinical & Laboratory Haematology, Christchurch Hospital NZ
- 1991 – 1992: Registrar, Internal Medicine, Waikato Hospital, Hamilton NZ
- 1990 : Senior House Officer, Internal Medicine, Brompton Hospital and St Georges Hospital, London UK
- 1988 – 1990: Intern in Medicine, Rotorua Hospital, NZ
Current Area of Research
- The interleukin-17 family of cytokines as mediators of transplant outcome
- Mechanisms of antigen presentation after transplantation
- Immunological mechanisms of leukaemia and myeloma eradication after transplantation
- Administration of an IL-6R antibody to prevent GVHD in clinical bone marrow transplant (BMT) recipients
- The use of type I interferons in preclinical and clinical BMT to improve the eradication of leukaemia
- The use of suicide gene-transfected effector after clinical haplo-identical BMT
- The use of regulatory T cells to treat clinical chronic GVHD
- Demonstrated the relationship between conditioning intensity and GVHD led to reduced intensity stem cell transplantation. Now half of all stem cell transplantation is undertaken in this fashion.
- Demonstrated the relationship of G-CSF mobilised blood products to GVHD/GVL. Now more than 80 per cent of transplantation is undertaken with G-CSF mobilised products.
- Demonstrated the ability and mode of action whereby growth factor administration after bone marrow transplantation (BMT) may exacerbate GVHD. G-CSF is now avoided after BMT.
- Demonstrated the critical role of Tumour Necrosis Factor TNF in mediating GVHD. TNF monoclonal antibodies (Enbrel) are now used routinely in clinical BMT.
- Defined the pathways of antigen presentation in the BMT setting and in particular the critical role of non-haematopoietic cells.
- Defined new populations of regulatory T cells that promote tolerance.
- Defined the role of interferons in modulating GVHD and promoting graft-versus-leukaemia (GVL) after BMT.
- 2003 – present: Australian Society of Bone Marrow Transplantation
- 2003 – present: American Society of Hematology
- 2003 – present: American Association of Immunology
- 2003 – present: American Society of Bone Marrow Transplantation
- 2002 – present: Australian Society of Immunology
- 1993 – present: Royal College Of Pathologists of Australasia
- 1993 – present: Transplantation Society Of Australia and NZ
- 1993 – present: Haematology Society of Australia and New Zealand
- 1993 – present: International Society for Haematology and Graft Engineering
- 1991 – present: Royal Australasian College of Physicians
- 2016: NHMRC Senior Principal Research Fellowship
- 2015: Fellow Australian Academy of Health and Medical Science
- 2014: Translational Research Institute National Research Prize
- 2011: Honorary NH&MRC Practitioner Fellow level 2
- 2011: QLD Health Senior Clinical Research Fellow
- 2011: NHMRC Australia Fellow
- 2011: Ralph Doherty QIMR prize
- 2009: Transplantation Society of Australia and NZ, Ian McKenzie Prize for Outstanding Contribution to the Field
- 2008: Professor, Griffith University
- 2007: QLD Cancer Fund (Top ranked grant in QLD)
- 2006: NH&MRC Practitioner Fellow level 1
- 2006: Rotary Paul Harris Fellowship
- 2005: “Queenslander of the Year”, Queensland State Government.
- 2005: Associate Professor, University of Queensland
- 2005: Associate Professor, Queensland University of Technology
- 2005: NHMRC: CIA of grant ranked in the top 10 highest achieving nationally
- 2005: McPerson Family Research Grant (QLD Cancer Fund, best state grant)
- 2001 – 2006: Wellcome Senior Research Fellow
- 2001 – 2005: Honorary NH&MRC Practitioner Fellow level 1
- 2001: Senior lecturer, University of Queensland
- 1998: Young Investigator Award, Transplantation Society of Australia and NZ
- 2001: MD, University Of Auckland (NZ)
- 1997: FRACP, Royal Australasian College of Physicians
- 1996: FRCPA, Royal College of Pathologists of Australasia
- 1988: MBChB, University Of Auckland (NZ)
- 1985: BHB, University Of Auckland (NZ)