The major focus of the Translational and Human Immunology group is to delineate the mechanisms that regulate human immune responses in health and disease. Knowledge gained from these studies forms the basis for developing novel immune interventional and diagnostic strategies which can implemented in clinical settings. Our group is also interested in understanding the transcriptional and epigenetic regulation of human immune responses during persistent viral infections and human cancers, and in developing strategies to manipulate this regulation to improve outcomes following immune intervention.
- Modelling immune dysfunction during primary EBV-infection
- Development of off-the-shelf cell therapies for solid tumours
- Programming of immunological memory to persistent viral infection
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