This group has focuses on three areas of research:
- Identification of host molecular pathways or immunological signals that contribute to protection against malaria.
- Understanding immunological signals that contribute to protection against cancer.
- Development of treatments for malaria and cancer.
Team Head: Dr Michelle Wykes
- Mr Joshua Horne-Debets, PhD Student
- Mr Deshapriya Karunarathne, Scientific Technical Officer
- Ji Liu, Research Assistant
- Rebecca Faleiro,
- Horne-Debets JM, Faleiro R, Karunarathne DS, Liu XQ, Lineburg KE, Poh CM, Grotenbreg GM, Hill GR, Macdonald KP, Good MF, et al. PD-1 Dependent Exhaustion of CD8(+) T Cells Drives Chronic Malaria. Cell Reports. 2013;5(5):1204-13.
- Karunarathne DS, Horne-Debets JM, Huang JX, Faleiro R, Leow CY, Amante F, Watkins TS, Miles JJ, Dwyer PJ, Stacey KJ, et al. Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4(+) T Cell Immunity. 2016;45(2):333-45.
- Horne-Debets JM, Karunarathne DS, Faleiro RJ, Poh CM, Renia L, and Wykes MN. Mice lacking Programmed cell death-1 show a role for CD8(+) T cells in long-term immunity against blood-stage malaria. Sci Rep. 2016;6(26210.
- Wykes MN, and Lewin SR. Immune checkpoint blockade in infectious diseases. Nat Rev Immunol. DOI: 10.1038/nri.2017.112
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