This group has focuses on three areas of research:
- Identification of host molecular pathways or immunological signals that contribute to protection against malaria.
- Investigating the pathogenesis of malaria.
- Development of treatments for malaria.
Team Head: Dr Michelle Wykes
- Mr Joshua Horne-Debets, PhD Student
- Mr Deshapriya Karunarathne, Scientific Technical Officer
Wykes M (2013) Why haven’t we made an efficacious vaccine for malaria? EMBO Reports.
Wykes MN, Horne-Debets J (2012) Dendritic cells: The Trojan horse of malaria? Int J Parasitol 42: 583-587.
Wykes MN (2012) Are plasmacytoid dendritic cells the misguided sentinels of malarial immunity? Trends Parasitol 28: 182-186.
Liu XQ, Stacey KJ, Horne-Debets JM, Cridland JA, Fischer K, Narum D, Mackay F, Pierce SK, Wykes MN (2012) Malaria infection alters the expression of B-cell activating factor resulting in diminished memory antibody responses and survival.Eur J Immunol 42: 3291-3301.
Wykes MN et al (2011) Rodent blood-stage Plasmodium survive in dendritic cells that infect naive mice. Proc Natl Acad Sci U S A 108: 11205-11210.
Wykes MN, Liu XQ, Beattie L, Stanisic DI, Stacey KJ, Smyth MJ, Thomas R, Good MF (2008) Plasmodium strain determines dendritic cell function essential for survival from malaria. International Journal for Parasitology 38: S76-S76.
Wykes MN, Good MF (2008) What really happens to dendritic cells during malaria?Nat Rev Microbiol 6: 864-867.
Wykes MN, Liu XQ, Jiang S, Hirunpetcharat C, Good MF (2007) Systemic tumor necrosis factor generated during lethal Plasmodium infections impairs dendritic cell function. J Immunol 179: 3982-3987.
Wykes MN, Liu XQ, Beattie L, Stanisic DI, Stacey KJ, Smyth MJ, Thomas R, Good MF (2007) Plasmodium Strain Determines Dendritic Cell Function Essential for Survival from Malaria. PLoS Pathog 3: e96.
Wykes M, Keighley C, Pinzon-Charry A, Good MF (2007) Dendritic cell biology during malaria. Cell Microbiol 9: 300-305.
Huang F-P, Platt N, Wykes M, Major JR, Powell TJ, Jenkins CD, MacPherson GG (2000) A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T cell Areas of Mesenteric Lymph Nodes. Journal of Experimental Medicine 191: 435-444.
Wykes M, Pombo A, Jenkins C, MacPherson GG (1998a) Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response. J Immunol 161: 1313-1319.
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