The Iron Metabolism Laboratory studies a wide spectrum of iron-related issues from basic mechanisms of iron homeostasis to disorders of iron metabolism. We are particularly interested in iron nutrition and iron deficiency, diseases of iron loading (haemochromatosis, thalassaemia and haemolytic anaemias) and the effects of iron on other conditions, notably cystic fibrosis. The laboratory seeks to do this by integrating genetic and molecular studies with biochemical and physiological approaches.
Much of our recent research has been based on understanding mechanisms of cellular iron transport and the way in which these processes are regulated. The group has a particular interest in studying intestinal iron absorption and body iron recycling, and how these processes are altered in disorders of iron metabolism. The role of the liver-derived hormone hepcidin, which regulates body iron transport, has been studied extensively.
The ultimate goal of our work is to improve the diagnosis and treatment of a range of conditions where iron metabolism is perturbed.
Group Leader: Professor Gregory Anderson
- Professor Lawrie Powell, Emeritus SPRF
- Dr David Frazer, Senior Research Officer
- Dr Linda Dunn, Research Officer
- Jeannette Dixon, Research Assistant
The main focus of the Iron Metabolism Laboratory is to understand the biology of the essential trace element, iron. In particular, we are interested in iron nutrition and the mechanism and regulation of intestinal iron absorption, human disorders where iron homeostasis is perturbed, and iron trafficking around the body.
- Mechanisms of hepatic encephalopathy – the role of manganese
- Using nanotechnology to deliver iron chelators
- A novel nanoparticulate iron supplement and its effect on the gastrointestinal tract
- Mechanisms of intestinal iron absorption in early infancy
- The uptake and toxicity of nanoparticles in the small intestine
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