The Immunology and Infection Laboratory studies host immune responses during malaria and leishmaniasis. Its aim is to distinguish anti-parasitic host immune responses that control infection from those that cause disease.
The laboratory uses experimental models, as well as samples from patients and human volunteers deliberately infected with parasites for our research. Particular interest is on understanding how T cells influence anti-parasitic immune responses.
The long-term goal of research is to develop better vaccines and therapies to prevent and treat infectious diseases.
Group Leader: Professor Christian Engwerda
- Dr Fiona Amante, Laboratory Manager
- Fabian De Labastida Rivera, Research Assistant
- Teija Frame, Honours Student
- Marcela Montes de Oca, Postdoctoral Fellow
The Immunology and Infection laboratory studies host immunity during infection. Our research aim is to identify immune responses that control infection and distinguish them from those that cause disease. The diseases we study are malaria and leishmaniasis, two important parasitic diseases responsible for much morbidity and mortality each year. We use experimental disease models, as well as samples from patients and human volunteers deliberately infected with parasites for our research. The long term goal of our research is to develop better vaccines and therapies to prevent and treat infectious diseases.
- Testing whether leishmanization can be used as a vaccine strategy against visceral forms of disease
- Discovering novel immune checkpoint molecules that can be manipulated for clinical advantage
- Identifying metabolic pathways used by regulatory T cells during infection
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