The HIV Molecular Virology Laboratory analyses human immunodeficiency virus (HIV) replication. This includes the process by which HIV is able to convert its genetic material composed of RNA into a form compatible with human DNA. Our focus is the discovery of key viral or cellular molecules required for HIV to grow, and then to target their action so that HIV growth can be effectively blocked. The lab is also interested in cellular factors regulating respiratory syncytial virus (RSV) and Hendra virus replication.
Warren, K., et al., Eukaryotic elongation factor 1 complex subunits are critical HIV-1 reverse transcription cofactors. Proc Natl Acad Sci U S A, 2012. 109(24): p. 9587-92.
Warrilow, D., K. Warren, and D. Harrich, Strand transfer and elongation of HIV-1 reverse transcription is facilitated by cell factors in vitro. PLoS One, 2010. 5(10): p. e13229.
Lin, M.-H., H. Sivakumaran, and D. Harrich, HIV gene therapy that’s not a SIN. HIV Therapy, 2010. 4(4): p. 395-398.
Warrilow, D., G. Tachedjian, and D. Harrich, Maturation of the HIV reverse transcription complex: putting the jigsaw together. Rev Med Virol, 2009. 19(6): p. 324-37.
Warren, K., et al., Reverse Transcriptase and Cellular Factors: Regulators of HIV-1 Reverse Transcription. Viruses, 2009. 1(3): p. 873-94.
Sivakumaran, H., et al., Arginine methylation increases the stability of human immunodeficiency virus type 1 Tat. J Virol, 2009. 83(22): p. 11694-703.
Meredith, L.W., et al., Potent inhibition of HIV-1 replication by a Tat mutant. PLoS One, 2009. 4(11): p. e7769.
Warrilow, D., et al., Cell factors stimulate human immunodeficiency virus type 1 reverse transcription in vitro. J Virol, 2008. 82(3): p. 1425-37.
Sivakumaran, H. and D. Harrich, SOCS1:a host factor required for HIV-1 Gag Trafficking. Future HIV Therapy, 2008. 2: p. 247-251.
Harrich, D., A. Apolloni, and D. Warrilow, HIV-1 Tat implicated as a key factor in viral spread. Future HIV Therapy, 2008. 2: p. 323-326.
Davis, A.J., et al., Human immunodeficiency virus type-1 reverse transcriptase exists as post-translationally modified forms in virions and cells. Retrovirology, 2008. 5: p. 115.
Warrilow, D., D. Stenzel, and D. Harrich, Isolated HIV-1 core is active for reverse transcription. Retrovirology, 2007. 4: p. 77.
Warrilow, D. and D. Harrich, HIV-1 replication from after cell entry to the nuclear periphery. Curr HIV Res, 2007. 5(3): p. 293-9.
Sivakumaran, H., et al., Functional relevance of nonsynonymous mutations in the HIV-1 tat gene within an epidemiologically-linked transmission cohort. Virol J, 2007. 4: p. 107.
Apolloni, A., et al., The HIV-1 Tat protein stimulates reverse transcription in vitro. Curr HIV Res, 2007. 5(5): p. 473-83.
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