The Functional Cancer Genomics Laboratory focuses on understanding how DNA variation contributes to cancer risk and development. The laboratory is particularly interested in translating the findings from genome-wide association studies (GWAS) for breast, ovarian, endometrial, prostate and skin (melanoma) cancers. This includes identification of the causal risk variants, connecting these variants to their target genes and understanding how the new genes contribute to cellular phenotypes associated with cancer development. We have already identified several molecular pathways that were not known to play a role in cancer that are suitable targets for drug repositioning or drug development. The ultimate aim of our research is to pave the way for future clinical trials for cancer prevention or treatment.
Team Head: Associate Professor Stacey Edwards
- Kristine Hillman, Research Assistant
- Susanne Kaufmann, Research Assistant
- Dr Haran Sivakumaran, Research Officer
Betts JA, Moradi MM, Al-Ejeh F….Edwards* SL, French* JD. 2017. Long non-coding RNAs, CUPID1 and CUPID2, mediate breast cancer risk at 11q13 by modulating response to DNA damage. American Journal of Human Genetics. (in press)
Michailidou K….Edwards SL, Bader GD, Chenevix-Trench G, Simard*J, Kraft* P, Easton* DF. 2017. Association analyses identifies 65 new breast cancer risk loci. Nature. (in press)
Dunning* AM….Easton* DF, Edwards* SL. 2016. Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170. Nature Genetics. PMID: 26928228
Ghoussaini, M… Dunning* AM, Edwards* SL. 2016. Evidence that the 5p12 variant rs10941679 confers susceptibility to estrogen receptor-positive breast cancer through FGF10 and MRPS30 regulation. American Journal of Human Genetics. PMID: 27640304
Painter JN….Edwards SL. 2016. A common variant at the 14q32 endometrial risk locus activates AKT1 through YY1 binding. American Journal of Human Genetics. PMID: 27259051
Cheng TH….Edwards SL, Easton DF, Tomlinson I, Spurdle AB. 2016. Five endometrial cancer risk loci identified through genome-wide association analysis. Nature Genetics. PMID: 27135401
Lawrenson K….Edwards SL, Chenevix-Trench* G, Antoniou* AC, Gayther* SA. 2016. Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus. Nature Communications. PMID: 27601076
French JD….Chenevix-Trench* G, DeFazio* A, Edwards* SL, MacGregor* S. 2016. Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer. Oncotarget. PMID: 26840454
Vincente* CT, Edwards* SL….French JD, Ferreira MA. 2015. Long-range modulation of PAG1 expression by 8q21 allergy risk variants. American Journal of Human Genetics. PMID: 26211970
Ghoussaini* M, Edwards* SL….Dunning AM. 2014. Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation. Nature Communication. PMID: 25248036
Edwards* SL, Beesley* J, French* JD, Dunning* AM. 2013. Beyond GWASs: illuminating the dark road from association to function. American Journal of Human Genetics. PMID: 24210251
Edwards SL, Brough R, Lord CJ, Natrajan R, Vatcheva R, Levine DA, Boyd J, Reis-Filho JS, Ashworth A. 2008. Resistance to therapy caused by intragenic deletion in BRCA2. Nature. PMID: 18264088
- Identifying new long-noncoding RNAs involved in breast cancer development
- Identification and evaluation of new breast cancer genes.
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