The Clinical Tropical Medicine Laboratory investigates how parasites such as the malaria parasite, hookworm, threadworm and scabies cause disease and how they become resistant to drugs used to treat them. The group also identifies new drugs and drug targets, and develops novel diagnostic techniques.
The laboratory’s focus is to apply modern techniques in microbiology, molecular biology and immunology to study clinical problems associated with infectious diseases in tropical environments.
A particular interest in this laboratory is the study of drug resistance in a range of parasites, and the development of novel diagnostic techniques.
Senior Scientist: Professor James McCarthy
- Associate Professor Katharine Trenholme, Senior Research Fellow
- Cielo Pasay, Postdoctoral staff
- Dr Katharine Collins, Postdoctoral staff
- Dr Silvana Sekuloski, Administrative staff
- Steve Turner, Administrative staff
- Dr Caroline Dobbin, Administrative staff
- Helen Jennings, Clinical Trials Project Manager
- Professor Michael Good, Visiting fellow
- Ms Karen Anderson, Technical staff
- Dr Paul Griffin, Visiting scientist
- Dr Qin Cheng, Group Leader
- Lewis Melville, Visiting scientist
- Kate Mounsey, Visiting scientist
McCarthy JS, Griffin PM, Sekuloski S, Bright AT, Rockett R, Looke D, Elliott S, Whiley D, Sloots T, Winzeler EA, Trenholme KR. (2013) Experimentally induced blood-stage Plasmodium vivax infection in healthy volunteers. The Journal of Infectious Diseases. 208(10):1688-94.
Rampton M, Walton SF, Holt DC, Pasay C, Kelly A, Currie BJ, McCarthy JS, Mounsey KE. (2013) Antibody responses to Sarcoptes scabiei apolipoprotein in a porcine model: relevance to immunodiagnosis of recent infection. PLoS One. 8(6):e65354.
Mounsey KE, McCarthy JS. (2013) Treatment and control of scabies. Current Opinion in Infectious Diseases. 2:133-9. Review.
Kline K, McCarthy JS, Pearson M, Loukas A, Hotez PJ. (2013) Neglected tropical diseases of Oceania: review of their prevalence, distribution, and opportunities for control. PLoS Neglected Tropical Diseases. 7(1):e1755. Review.
McCarthy JS, Sekuloski S, Griffin PM, Elliott S, Douglas N, Peatey C, Rockett R, O’Rourke P, Marquart L, Hermsen C, Duparc S, Möhrle J, Trenholme KR, Humberstone AJ. (2011) A pilot randomised trial of induced blood-stage Plasmodium falciparum infections in healthy volunteers for testing efficacy of new antimalarial drugs. PLoS One. 8:e21914.
McCarthy JS, Marjason J, Elliott S, Fahey P, Bang G, Malkin E, Tierney E, Aked-Hurditch H, Adda C, Cross N, Richards JS, Fowkes FJ, Boyle MJ, Long C, Druilhe P, Beeson JG, Anders RF. (2011) A phase 1 trial of MSP2-C1, a blood-stage malaria vaccine containing 2 isoforms of MSP2 formulated with Montanide® ISA 720. PLoS One. 6(9):e24413.
Currie BJ, McCarthy JS. (2010) Permethrin and ivermectin for scabies. The New England Journal of Medicine. 362(8):717-25. Review.
Pinzon-Charry A, McPhun V, Kienzle V, Hirunpetcharat C, Engwerda C, McCarthy J, Good MF. (2010) Low doses of killed parasite in CpG elicit vigorous CD4+ T cell responses against blood-stage malaria in mice. The Journal of Clinical Investigation. 120(8):2967-78.
Kotze, A.C., Coleman, G.T., Mai, A. and McCarthy, J.S. (2005) Field evaluation of anthelmintic drug sensitivity using in vitro egg hatch and larval motility assays with Necator americanus recovered from human clinical isolates. International Journal for Parasitology 35: 445-453.
McCarthy, J.S. (2005) Malaria chemoprophylaxis: in war and peace. Medical Journal of Australia 182: 148-149.
Currie, B.J. and McCarthy, J.S. (2005) Strongyloides stercoralis infection as a manifestation of immune restoration syndrome? Clinical Infectious Diseases 40: 635.
McCarthy, J.S., Kemp, D.J., Walton, S.F. and Currie, B.J. (2004) Scabies: more than an irritation. Postgraduate Medical Journal 80: 382-387.
Geraghty, C.M. and McCarthy, J.S. (2004) Japanese encephalitis vaccine: is it being sufficiently used in travellers? Medical Journal of Australia 181: 269-270.
Skinner-Adams, T.S., McCarthy, J.S., Gardiner, D.L., Hilton, P.M. and Andrews, K.T. (2004) Antiretrovirals as antimalarial agents. Journal of Infectious Diseases 190: 1998-2000.
Kotze, A.C., Clifford, S., O’Grady, J., Behnke, J.M. and McCarthy, J.S. (2004) An in vitro larval motility assay to determine anthelmintic sensitivity for human hookworm and Strongyloides species. American Journal of Tropical Medicine and Hygiene 71: 608-616.
Wu, Y., Egerton, G., McCarthy, J.S., Nutman, T.B. and Bianco, A.E. (2003) Human immune responses to infective stage larval-specific chitinase of filarial parasite, Onchocerca volvulus, Ov-CHI-1. Filaria Journal 2: 6.
McCarthy, J.S., Wieseman, M., Tropea, J., Kaslow, D., Abraham, D., Lustigman, S., Tuan, R., Guderian, R.H. and Nutman, T.B. (2002) Ochocerca volvulus glycolytic enzyme fructose-1, 6-biphosphate aldolase as a target for a protective immune response in humans. Infection and Immunity 70: 851-858.
McCarthy JS, Weisman M, Tropea J, Kaslow D, Tuan R and Nutman TB. (2002) Fructose bisphosphate aldolase: a major antigen in human Onchocerca volvulus infection. Infection and Immunity 70(2):851-8.
McCarthy JS and Garrow SC. Parasite elimination programs: at home and away (Editorial). (2002) Medical Journal of Australia 176 (10):456-457.
McCarthy JS, Peacock D, Trown K, Bade P, Petri W and Currie B. (2002) Endemic invasive amoebiasis in northern Australia.Medical Journal of Australia 177(10):570.
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