The Cancer Genetics Laboratory investigates why some people get cancer, and how these cancers, particularly those of the breast, ovary and stomach, develop from a normal cell. The laboratory also looks at why these cancers are often found together in the same families and share many similar characteristics.
In particular, research seeks to discover other genes that might predispose to breast or ovarian cancer, using families from the Australasian consortium of familial breast cancer, kConFab, to identify high-penetrance genes, and case-control studies to identify low-penetrance genes. In addition, the laboratory is studying an inherited form of gastric cancer which has been recently described.
The laboratory also has an interest in genes involved in response to chemotherapy in ovarian cancer patients, and has undertaken a genome-wide association study in cases from the Australian Ovarian Cancer Study, with validation in additional cases from the Ovarian Association Consortium.
Senior Scientist: Professor Georgia Chenevix-Trench
- Dr Jonathan Beesley, Senior Research Officer
- Dr Jun Jun Li, Research Officer
- Dr Karen McCue, Research Officer
- Dr Wei Shi, Research Officer
- Dr Xiao Qing Chen, Lab Manager and Research Assistant
- Anna Marsh, Research Assistant
- Martina Toso, PhD Student
More information for students:
- Germline variation underlying individual differences in risk of, and outcome from, breast and ovarian cancer
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