The Cancer Genetics Laboratory investigates why some people get cancer, and how these cancers, particularly those of the breast, ovary and stomach, develop from a normal cell. The laboratory also looks at why these cancers are often found together in the same families and share many similar characteristics.
We are looking for other genes that might predispose to breast or ovarian cancer, using families from the Australasian consortium of familial breast cancer, kConFab, to identify high-penetrance genes, and case-control studies to identify low-penetrance genes. In addition, the laboratory is studying an inherited form of gastric cancer which we have recently described.
The laboratory also has an interest in genes involved in response to chemotherapy in ovarian cancer patients, and have done a genome-wide association study in cases from the Australian Ovarian Cancer Study, with validation in additional cases from the Ovarian Association Consortium.
Senior Scientist: Professor Georgia Chenevix-Trench
- Dr Jonathan Beesley, Senior Research Officer
- Dr Jun Jun Li, Research Officer
- Dr Karen McCue, Research Officer
- Dr Wei Shi, Research Officer
- Dr Xiao Qing Chen, Lab Manager and Research Assistant
- Anna Marsh, Research Assistant
- Martina Toso, PhD Student
Inherited predisposition to breast and ovarian cancer is caused in part by mutations in the BRCA1 and BRCA2 genes, but only about one third of families with a strong family history of breast cancer carry mutations in these genes. We are looking for other genes which might predispose to breast or ovarian cancer, using families from the Australasian consortium of familial breast cancer, kConFab, to identify high-penetrance genes and case-control studies to identify low-penetrance genes.
Furthermore, BRCA1/2 mutations show incomplete penetrance and variable expression. In collaboration with the international Consortium for Investigators of Modifiers of BRCA1/2 (CIMBA), we are studying BRCA1/2 mutation carriers in order to identify genes that modify the expression of BRCA1/2.
We also have an interest in genes involved in response to chemotherapy in ovarian cancer patients, and plan to do a genome-wide association study of this train in cases from the Australian Ovarian Cancer Study.
- Identification of the gene for Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS syndrome) by exome and genome sequencing
- Somatic mutations in basal-like breast tumours, and in brain metastases
- Next generation sequencing approaches to finding novel breast cancer susceptibility genes
- Genes involved in intrinsic resistance to chemotherapy in patients with ovarian cancer
- Germline variation underlying individual differences in risk of breast and ovarian cancer
More information for students:
- Germline variation underlying individual differences in risk of, and outcome from, breast and ovarian cancer
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