The Cancer Drug Mechanisms Laboratory combines expertise in cancer biology with drug studies.
Its cancer biology work currently focuses on understanding the development and progression of cancers of the skin and oral cavity. Specifically, the laboratory is investigating the molecular mechanisms involved in the progression and metastasis of melanoma, head and neck cancer, as well as cutaneous squamous cell carcinoma. These molecular mechanisms also impact on drug resistance of cancers. The identification and understanding of aberrantly regulated pathways in these cancers is crucial prior to the design or identification of suitable agents to treat the diseases.
Group Leader: Dr Glen Boyle
- Dr Jacinta Simmons, Research Officer
- Courtenay Henrys, Research Officer
Boyle, G.M., Woods, S.L., Bonazzi, V.F., Stark, M.S., Hacker, E., Aoude, L.G., Dutton-Regester, K., Cook, A.L., Sturm, R.A. and Hayward, N.K. (2011) Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor. Pigment Cell Melanoma Res. 24, 525-537.
Yokoyama, S.,* Woods, S.L.,* Boyle, G.M.,* Aoude, L.G.,* MacGregor, S.,* Zismann, V.,* Gartside, M., Cust, A.E., Haq, R., Harland, M., Taylor, J., Duffy, D.L., Holohan, K., Dutton-Regester, K., Palmer, J.M., Bonazzi, V., Stark, M.S., Symmons, J., Law, M.H., Schmidt, C., Lanagan, C., O’Connor, L., Holland, E.A., Schmid, H., Maskiell, J.A., Jetann, J., Ferguson, M., Jenkins, M.A., Kefford, R.F., Giles, G.G., Armstrong, B.K., Aitken, J.F., Hopper, J.L., Whiteman, D.C., Pharoah, P.D., Easton, D.F., Dunning, A.M., Newton-Bishop, J.A., Montgomery, G.W., Martin, N.G., Mann, G.J., Bishop, D.T., Tsao, H., Trent, J.M., Fisher, D.E., Hayward, N.K. and Brown, K.M. (2011) A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma. Nature. 480, 99-103. * Authors contributed equally.
Warren, T.A., Broit, N., Simmons, J.L., Pierce, C.J., Chawla, S., Lambie, D.L.J., Quagliotto, G., Brown, I.S., Parsons, P.G., Panizza, B.J. and Boyle, G.M. (2016) Expression profiling of cutaneous squamous cell carcinoma with perineural invasion implicates the p53 pathway in the process. Sci. Reports. 6, 34081.
Simmons, J.L., Pierce, C.J., Al-Ejeh, F. and Boyle, G.M. (2017) MITF and BRN2 contribute to metastatic growth after dissemination of melanoma. Sci. Reports. 7, 10909.
- Is dual loss of MITF and BRN2 responsible for melanoma treatment insensitivity?
- How are MITF and BRN2 involved in melanoma progression?
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