The Army Malaria Institute (AMI) Laboratory consolidates close collaborations between QIMR Berghofer and the Australian Army Malaria Institute that have existed for many years. The lab head, Dr Qin Cheng, was a QIMR scientist between 1989 and 1998, and has been a Visiting Scientist since 1998.
The laboratory consists of both QIMR Berghofer employees and AMI staff. The mission of the laboratory is to facilitate research collaborations between QIMR Berghofer and AMI. Our collaborations focus on malaria research, and investigate biological and molecular changes that make parasites difficult to detect and more resistant to anti-malarial drugs. Our research outcomes inform malaria control and elimination policy and strategies. We also plan to expand our research scope into arbovirus related research in future.
The laboratory was initially established at QIMR in 2004 and called the Malaria Drug Resistance and Chemotherapy Laboratory (2004-2012). The laboratory was funded mainly from NIH and NHMRC grants. Between 2013 and 2016, we joined the Clinical Tropical Medicine Laboratory at QIMR Berghofer.
Group Leader: Dr Qin Cheng
- Ms Karen Anderson, Technical staff
- Karryn Gresty, Research Assistant
- Dr Chris Peatey, Affiliate
Donald W, Pasay C, Guintran JO, Iata H, Anderson K, Nausien J, Gresty KJ, Waters NC, Vestergaard LS, Taleo G, Cheng Q. 2016. The Utility of Malaria Rapid Diagnostic Tests as a Tool in Enhanced Surveillance for Malaria Elimination in Vanuatu. PLoS One 11:e0167136.
Gray KA, Gresty KJ, Chen N, Zhang V, Gutteridge CE, Peatey CL, Chavchich M, Waters NC, Cheng Q. 2016. Correlation between Cyclin Dependent Kinases and Artemisinin-Induced Dormancy in Plasmodium falciparum In Vitro. PLoS One 11:e0157906.
Cheng Q, Cunningham J, Gatton ML. 2015. Systematic Review of Sub-microscopic P. vivax Infections: Prevalence and Determining Factors. PLoS Negl Trop Dis 9:e3413.
Peatey CL, Chavchich M, Chen N, Gresty KJ, Gray KA, Gatton ML, Waters NC, Cheng Q. 2015. Mitochondrial membrane potential in a small subset of artemisinin-induced dormant Plasmodium falciparum parasites in vitro. J Infect Dis 212:426-34.
Ho MF, Baker J, Lee N, Luchavez J, Ariey F, Nhem S, Oyibo W, Bell D, Gonzalez I, Chiodini P, Gatton ML, Cheng Q, McCarthy JS. 2014. Circulating antibodies against Plasmodium falciparum histidine-rich proteins 2 interfere with antigen detection by rapid diagnostic tests.
Cheng Q, Gatton ML, Barnwell J, Chiodini P, McCarthy J, Bell D, Cunningham J. 2014. Plasmodium falciparum parasites lacking histidine-rich protein 2 and 3: a review and recommendations for accurate reporting. Malar J 13:283.Malar J 13:480.
Chen N, LaCrue AN, Teuscher F, Waters NC, Gatton ML, Kyle DE, Cheng Q. 2014. Fatty acid synthesis and pyruvate metabolism pathways remain active in dihydroartemisinin-induced dormant ring stages of Plasmodium falciparum. Antimicrob Agents Chemother 58:4773-81.
Gray KA, Dowd S, Bain L, Bobogare A, Wini L, Shanks GD, Cheng Q. 2013. Population genetics of Plasmodium falciparum and Plasmodium vivax and asymptomatic malaria in Temotu Province, Solomon Islands. Malar J 12:429.
Lee N, Gatton ML, Pelecanos A, Bubb M, Gonzalez I, Bell D, Cheng Q, McCarthy JS. 2012. Identification of optimal epitopes for Plasmodium falciparum Rapid Diagnostic Tests that target histidine-rich proteins 2 and 3. J Clin Microbiol.
Teuscher F, Chen N, Kyle DE, Gatton ML, Cheng Q. 2012. Phenotypic changes in artemisinin-resistant Plasmodium falciparum lines in vitro: evidence for decreased sensitivity to dormancy and growth inhibition. Antimicrob Agents Chemother 56:428-31.
Price RN, Auburn S, Marfurt J, Cheng Q. 2012. Phenotypic and genotypic characterisation of drug-resistant Plasmodium vivax. Trends Parasitol 28:522-9.
Auliff AM, Balu B, Chen N, O’Neil MT, Cheng Q, Adams JH. 2012. Functional analysis of Plasmodium vivax dihydrofolate reductase-thymidylate synthase genes through stable transformation of Plasmodium falciparum. PLoS One 7:e40416.
Cheng Q, Kyle DE, Gatton ML. 2012. Artemisinin resistance in Plasmodium falciparum: A process linked to dormancy? Int J Parasitol Drugs Drug Resist 2:249-255.
Baker J, Gatton ML, Peters J, Ho MF, McCarthy JS, Cheng Q. 2011. Transcription and expression of Plasmodium falciparum histidine-rich proteins in different stages and strains: implications for rapid diagnostic tests. PLoS One 6:e22593.
Teuscher F, Gatton ML, Chen N, Peters J, Kyle DE, Cheng Q. 2010. Artemisinin-induced dormancy in Plasmodium falciparum: duration, recovery rates, and implications in treatment failure. J Infect Dis 202:1362-8.
Harris I, Sharrock WW, Bain LM, Gray KA, Bobogare A, Boaz L, Lilley K, Krause D, Vallely A, Johnson ML, Gatton ML, Shanks GD, Cheng Q. 2010. A large proportion of asymptomatic Plasmodium infections with low and sub-microscopic parasite densities in the low transmission setting of Temotu Province, Solomon Islands: challenges for malaria diagnostics in an elimination setting. Malar J 9:254.
Gamboa D, Ho MF, Bendezu J, Torres K, Chiodini PL, Barnwell JW, Incardona S, Perkins M, Bell D, McCarthy J, Cheng Q. 2010. A large proportion of P. falciparum isolates in the Amazon region of Peru lack pfhrp2 and pfhrp3: implications for malaria rapid diagnostic tests. PLoS One 5:e8091.
Chen N, Chavchich M, Peters JM, Kyle DE, Gatton ML, Cheng Q. 2010. Deamplification of pfmdr1-containing amplicon on chromosome 5 in Plasmodium falciparum is associated with reduced resistance to artelinic acid in vitro. Antimicrob Agents Chemother 54:3395-401.
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