- 25 May 2017
1:00 pm - 2:00 pm
Thursday 25 May 2017, 1.00 PM
Auditorium, Level 6, Bancroft Building
New approaches to predicting target genes for Breast Cancer risk
Professor Georgia Chenevix-Trench
QIMR Berghofer Medical Research Institute
The major challenge, now that so many risk loci have been identified, is to determine which of the genes nearby are targeted by the risk SNPs. Georgia will discuss new approaches that her lab has led to develop a bioinformatics pipeline to predict the target genes for breast cancer risk, and the application and in vitro validation of transcription wide association studies. She will also present some recent results from CIMBA showing the utility of applying polygenic risk scores to predicting cancer risk for male and female BRCA1/2 carriers, and present the recent discovery of the first locus associated with outcome in ovarian cancer which implicates ULK1 a gene involved in autophagy.
Georgia Chenevix-Trench is the head of the Department of Genetics and Computational Biology, and of the Cancer Genetics Laboratory at the QIMR Berghofer. She is the author of more than 420 papers, and has been instrumental in the collection of public resources such as kConFab, the Australian consortium for research into familial breast cancer. She is the leader of the international Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA), and a founding member of the Breast and Ovarian Cancer Association Consortia, which have identified over 200 novel breast and ovarian cancer susceptibility loci since the advent of genome-wide association studies.